Direct, ChemoselectiveN-tert-Prenylation of Indoles by CH Functionalization
نویسندگان
چکیده
منابع مشابه
Efficient direct 2,2,2-trifluoroethylation of indoles via C-H functionalization.
A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of ...
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The development of multicomponent reactions for indole synthesis is demanding and has hardly been explored. The present study describes the development of a novel multicomponent, cascade approach for indole synthesis. Various substituted indole derivatives were obtained from simple reagents, such as unfunctionalized alkenes, diazonium salts, and sodium triflinate, by using an established straig...
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Significance: The authors developed a gold-catalyzed hydroamination followed by an asymmetric nucleophilic allylic substitution cascade to access oxazino[4,3-a]indoles in good yields and enantioselectivities. Owing to pharmacologically active indole alkaloids, this rapid synthesis and asymmetric decoration of the polycyclic indolyl core is highly important. Comment: Amazingly, the stereodiffere...
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2009
ISSN: 1433-7851,1521-3773
DOI: 10.1002/anie.200902761